Our laboratory investigates molecular and epigenetic regulation of blood pressure, particularly the application of molecular, cellular and transgenic approaches to the understanding of complex physiological function.
Our research areas of interest include integrative cardiovascular physiology, endocrinology, and neuroscience, with major focuses on the molecular and cellular basis of hypertension and cardiac hypertrophy, genetic and epigenetic mechanisms of heart failure and aortic valve calcification, neuroendocrine control of circulation, molecular intervention for diabetes, anti-aging, and more. Our team discovered an important role of Klotho, an anti-aging enzyme, in the pathogenesis of hypertension, and our most recent efforts focus on stem cell-derived exosomes, DNA methylation and histone modification in the pathogenesis of arterial stiffness and heart diseases.
