Publications

Lab Publications

Ullah M, Sun Z. Klotho deficiency accelerates stem cells aging by impairing telomerase activity. J Gerontol A Biol Sci Med Sci. 2018 Nov 18. doi: 10.1093/gerona/gly261. [Epub ahead of print] PMID: 30452555

Ullah M, Sun Z. Stem cells and anti-aging genes: double-edged sword do the same job of life extension. Stem Cell Res Ther. 2018 Jan 10;9(1):3. doi: 10.1186/s13287-017-0746-4. Review. PMID: 29321045

Xu Y, Sun Z. Regulation of S-formylgluthathione hydrolase by the anti-aging gene klotho. Oncotarget. 2017 Jul 8;8(51):88259-88275. doi: 10.18632/oncotarget.19111. eCollection 2017 Oct 24. PMID: 29179433

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A special report on the NHLBI initiative to study cellular and molecular mechanisms of arterial stiffness and its association with hypertension. Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. No abstract available. PMID: 29122942

Jung D, Xu Y, Sun Z. Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. Oncotarget. 2017 Jul 18;8(29):46745-46755. doi: 10.18632/oncotarget.18608. PMID: 28657902

Chen PG, Sun Z. AAV delivery of endothelin-1 shRNA attenuates cold-induced hypertension. Hum Gene Ther. 2017 Feb;28(2):190-199. doi: 10.1089/hum.2016.047. Epub 2016 Oct 11. Review. PMID: 27736201

Varshney R, Ali Q, Wu C, Sun Z. Monocrotaline-induced pulmonary hypertension involves downregulation of antiaging protein klotho and eNOS activity. Hypertension. 2016 Nov;68(5):1255-1263. Epub 2016 Sep 26. PMID: 27672025

Gao D, Zuo Z, Tian J, Ali Q, Lin Y, Lei H, Sun Z. Activation of SIRT1 attenuates klotho deficiency-induced arterial stiffness and hypertension by enhancing AMP-activated protein kinase activity. Hypertension. 2016 Nov;68(5):1191-1199. Epub 2Gao D,016 Sep 12. PMID: 27620389

Chen J, Lin Y, Sun Z. Deficiency in the anti-aging gene klotho promotes aortic valve fibrosis through AMPKa-mediated activation of RUNX2. Aging Cell. 2016 Oct;15(5):853-60. doi: 10.1111/acel.12494. Epub 2016 May 31. PMID: 27242197

Fan J, Sun Z. The antiaging gene klotho regulates proliferation and differentiation of adipose-derived stem cells. Stem Cells. 2016 Jun;34(6):1615-25. doi: 10.1002/stem.2305. Epub 2016 Feb 26. PMID: 26865060

Lin Y, Chen J, Sun Z. Antiaging gene klotho deficiency promoted high-fat diet-induced arterial stiffening via inactivation of AMP-activated protein kinase. Hypertension. 2016 Mar;67(3):564-73. doi: 10.1161/HYPERTENSIONAHA.115.06825. Epub 2016 Jan 18. PMID: 26781278

Lin Y, Sun Z. Antiaging gene klotho attenuates pancreatic β-cell apoptosis in Type 1 diabetes. Diabetes. 2015 Dec;64(12):4298-311. doi: 10.2337/db15-0066. Epub 2015 Sep 4. PMID: 26340932

Xu Y, Sun Z. Molecular basis of klotho: from gene to function in aging. Endocr Rev. 2015 Apr;36(2):174-93. doi: 10.1210/er.2013-1079. Epub 2015 Feb 19. Review. PMID: 25695404

Sun Q, Zhang Z, Sun Z. The potential and challenges of using stem cells for cardiovascular repair and regeneration. Genes Dis. 2014 Sep 1;1(1):113-119. PMID: 25642448

Lin Y, Sun Z. In vivo pancreatic β-cell-specific expression of antiaging gene klotho: a novel approach for preserving β-cells in type 2 diabetes. Diabetes. 2015 Apr;64(4):1444-58. doi: 10.2337/db14-0632. Epub 2014 Nov 5. PMID: 25377875

Sun Z. Aging, arterial stiffness, and hypertension. Hypertension. 2015 Feb;65(2):252-6. doi: 10.1161/HYPERTENSIONAHA.114.03617. Epub 2014 Nov 3. Review. No abstract available. PMID: 25368028

Crosswhite P, Chen K, Sun Z. AAV delivery of tumor necrosis factor-α short hairpin RNA attenuates cold-induced pulmonary hypertension and pulmonary arterial remodeling. Hypertension. 2014 Nov;64(5):1141-50. doi: 10.1161/HYPERTENSIONAHA.114.03791. Epub 2014 Sep 2. PMID: 25185133

Wang Y, Sun Z. Antiaging gene klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J Hypertens. 2014 Aug;32(8):1629-36; discussion 1636. doi: 10.1097/HJH.000000000000023. PMID: 24979306

Sun Z. Platelet TLR4: a critical link in pulmonary arterial hypertension. Circ Res. 2014 May 9;114(10):1551-3. doi: 10.1161/CIRCRESAHA.114.303945. No abstract available. PMID: 24812346

Crosswhite P, Sun Z. Molecular mechanisms of pulmonary arterial remodeling. Mol Med. 2014 Apr 22;20:191-201. doi: 10.2119/molmed.2013.00165. Review. PMID: 24676136

Lin Y, Kuro-o M, Sun Z. Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology. 2013 Oct;154(10):3855-63. doi: 10.1210/en.2013-1053. Epub 2013 Aug 8. PMID: 23928372

Benbrook DM, Guruswamy S, Wang Y, Sun Z, Mohammed A, Zhang Y, Li Q, Rao CV. Chemoprevention of colon and small intestinal tumorigenesis in APC(min/+) mice by SHetA2 (NSC721689) without toxicity. Cancer Prev Res (Phila). 2013 Sep;6(9):908-16. doi: 10.1158/1940-6207.CAPR-13-0171. Epub 2013 Jul 12. PMID: 23852423

Sun Z, Lei H, Zhang Z. Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions. Cytokine Growth Factor Rev. 2013 Oct;24(5):433-42. doi: 10.1016/j.cytogfr.2013.05.006. Epub 2013 Jun 17. Review. PMID: 23787158

Crosswhite P, Sun Z. Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension. Hypertension. 2013 Mar;61(3):585-92. doi: 10.1161/HYPERTENSIONAHA.111.00676. Epub 2013 Jan 14. PMID: 23319544

Wang X, Skelley L, Wang B, Mejia A, Sapozhnikov V, Sun Z. AAV-based RNAi silencing of NADPH oxidase gp91(phox) attenuates cold-induced cardiovascular dysfunction. Hum Gene Ther. 2012 Sep;23(9):1016-26. doi: 10.1089/hum.2012.078. Epub 2012 Aug 13. PMID: 22888847

Wang X, Wang Q, Sun Z. Normal lgG downregulates the intracellular superoxide level and attenuates migration and permeability in human aortic endothelial cells isolated from a hypertensive patient. Hypertension. 2012 Sep;60(3):818-26. doi: 10.1161/HYPERTENSIONAHA.112.199281. Epub 2012 Jul 9. PMID: 22777940

Sun Z, Moreno C, Zhuo JL, Miller L, Joe B. Celebrating physiological genomics at the 125th anniversary of the American Physiological Society. Physiol Genomics. 2012 Jul 15;44(14):699-701. doi: 10.1152/physiolgenomics.00063.2012. Epub 2012 May 29. No abstract available. PMID: 22643062

Lin Y, Sun Z. Antiaging gene klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells. Endocrinology. 2012 Jul;153(7):3029-39. doi: 10.1210/en.2012-1091. Epub 2012 May 17. PMID: 22597535

Wang Y, Kuro-o M, Sun Z. Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell. 2012 Jun;11(3):410-7. doi: 10.1111/j.1474-9726.2012.00796.x. Epub 2012 Feb 22. PMID: 22260450

Dammanahalli JK, Wang X, Sun Z. Genetic interleukin-10 deficiency causes vascular remodeling via the upregulation of Nox1. J Hypertens. 2011 Nov;29(11):2116-25. doi: 10.1097/HJH.0b013e32834b22a0. PMID: 21918473

Lin Y, Sun Z. Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes. J Cell Physiol. 2011 Oct;226(10):2625-32. doi: 10.1002/jcp.22613. PMID: 21792921

Lin Y, Sun Z. Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes. J Endocrinol. 2011 May;209(2):185-91. doi: 10.1530/JOE-10-0340. Epub 2011 Feb 9. PMID: 21307121

Lin Y, Sun Z. Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes. Br J Pharmacol. 2011 Feb;162(3):597-610. doi: 10.1111/j.1476-5381.2010.01056.x. PMID: 20883475

Zuo Z, Lei H, Wang X, Wang Y, Sonntag W, Sun Z. Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordr). 2011 Sep;33(3):261-74. doi: 10.1007/s11357-010-9176-2. Epub 2010 Sep 10. PMID: 20830528

Du L, Wu W, Zhang Y, Sun Z, Hu H, Liu X, Liu Q. Effects of modified splenocaval shunt plus devascularization on esophagogastric variceal bleeding: a comparative study of this treatment and devascularization only in cirrhotic portal hypertension. J Hepatobiliary Pancreat Sci. 2010 Sep;17(5):657-65. doi: 10.1007/s00534-010-0262-8. Epub 2010 Mar 2. PMID: 20703844

Galligan J, Sun Z. NIH director’s priorities: opportunities for physiology. Physiologist. 2010 Jun;53(3):80-1. No abstract available. PMID: 20550008

Wang X, Sun Z. Thyroid hormone induces artery smooth muscle cell proliferation: discovery of a new TRalpha1-Nox1 pathway. J Cell Mol Med. 2010 Jan;14(1-2):368-80. PMID: 20414976

Crosswhite P, Sun Z. Ribonucleic acid interference knockdown of interleukin 6 attenuates cold-induced hypertension. Hypertension. 2010 Jun;55(6):1484-91. doi: 10.1161/HYPERTENSIONAHA.109.146902. Epub 2010 Apr 12. PMID: 20385973

Wang X, Sun Z. RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway. Physiol Genomics. 2010 Apr 1;41(2):120-6. doi: 10.1152/physiolgenomics.00192.2009. Epub 2010 Jan 19. PMID: 20086041

Crosswhite P, Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J Hypertens. 2010 Feb;28(2):201-12. doi: 10.1097/HJH.0b013e328332bcdb. Review. PMID: 20051913

Sun Z. Cardiovascular responses to cold exposure. Front Biosci (Elite Ed). 2010 Jan 1;2:495-503. Review. PMID: 20036896

Lin Y, Sun Z. Current views on type 2 diabetes. J Endocrinol. 2010 Jan;204(1):1-11. doi: 10.1677/JOE-09-0260. Epub 2009 Sep 21. Review. PMID: 19770178

Wang Y, Sun Z. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension. 2009 Oct;54(4):810-7. doi: 10.1161/HYPERTENSIONAHA.109.134320. Epub 2009 Jul 27. PMID: 19635988

Wang Y, Sun Z. Current understanding of klotho. Ageing Res Rev. 2009 Jan;8(1):43-51. doi: 10.1016/j.arr.2008.10.002. Epub 2008 Oct 31. Review. PMID: 19022406

Dammanahalli JK, Sun Z. Endothelin (ET)-1 inhibits nicotinamide adenin dinucleotide phosphate oxidase activity in human abdominal aortic endothelial cells: a novel function of ETB1 receptors. Endocrinology. 2008 Oct;149(10):4979-87. doi: 10.1210/en.2008-0199. Epub 2008 Jun 5. PMID: 18535108

Sun Z, Bello-Roufai M, Wang X. RNAi inhibition of mineralocorticoid receptors prevents the development of cold-induced hypertension. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1880-7. doi: 10.1152/ajpheart.01319.2007. Epub 2008 Feb 22. PMID: 18296563

Dammanahalli KJ, Sun Z. Endothelins and NADPH oxidases in the cardiovascular system. Clin Exp Pharmacol Physiol. 2008 Jan;35(1):2-6. Review. PMID: 18047620

Sun Z. Overview of recent advances in molecular cardiology. Can J Cardiol. 2006 Mar 1;22(3):235-40. Review. PMID: 16520855

Sun Z. Genetic AVP deficiency abolishes cold-induced diuresis but does not attenuate cold-induced hypertension. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1472-7. Epub 2006 Jan 5. PMID: 16396942

Chen GF, Sun Z. Effects of chronic cold exposure on the endothelin system. J Appl Physiol. 2006 May;100(5):1719-26. Epub 2005 Dec 29. PMID: 1638483

Wang X, Sun Z, Cade R. Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense. Kidney Int. 2005 Aug;68(2):680-7. PMID: 16014045

Wang X, Cade R, Sun Z. Expression of human eNOS in cardiac and endothelial cells. Methods Mol Med. 2005;112:91-107. Review. PMID: 16010013

Sun Z. Introduction to methods in molecular cardiology. Methods Mol Med. 2005;112:3-12. Review. PMID: 16010007

Wang X, Cade R, Sun Z. Human eNOS gene delivery attenuates cold-induced elevation of blood pressure in rats. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1161-8. Epub 2005 May 13. PMID: 15894566

Sun Z, Wang X, Wood CE, Cade JR. Genetic AT1A receptor deficiency attenuates cold-induced hypertension. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R433-9. Epub 2004 Oct 21. PMID: 15498966

Sun Z, Zhang Z, Wang X, Cade R, Elmir Z, Fregly M. Relation of beta-casomorphin to apnea in sudden infant death syndrome. Peptides. 2003 Jun;24(6):937-43. Review. PMID: 12948848

Sun Z, Cade R. Findings in normal rats following administration of gliadorphin-7 (GD-7). Peptides. 2003 Feb;24(2):321-3. PMID: 12668219

Sun Z, Zhang Z, Cade R. Renal responses to chronic cold exposure. Can J Physiol Pharmacol. 2003 Jan;81(1):22-7. PMID: 12665254

Sun Z, Cade R, Zhang Z, Alouidor J, Van H. Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension. 2003 Feb;41(2):322-7. PMID: 12574102

Sun Z, Cade R, Morales C. Role of central angiotensin II receptors in cold-induced hypertension. Am J Hypertens. 2002 Jan;15(1 Pt 1):85-92. PMID: 11824866